Journal: Current biology : CB

Article Title: Divergent strategies for learning in males and females

doi: 10.1016/j.cub.2020.09.075

Figure Lengend Snippet: A) cFos gene expression (qRT-PCR) in five brain regions: nucleus accumbens (NAc), dorsal medial striatum (DMS), amygdala (AMY), hippocampus (HPC), and prefrontal cortex (PFC). Female mice showed elevated c-fos expression across all five brain regions. Extracted brain sections for each brain region are shown in the altas. B) regression coefficient of c-fos expression in NAc and PFC, and sex in predicting the use of PC2 strategy C) Heatmap of correlation matrix of c-fos expression level among five brain regions. Colorbar = Pearson’s r. D) cFos gene expression in NAc and PFC is significantly correlated with the weight of PC2. E) Median split of c-fos expression in NAc and PFC and PC2 scores within each sex. F) Sex mediated the relationship between c-fos expression in NAc and PFC and PC2 scores.The top models demonstrate thedirect effect and the bottom models demonstrate the mediated effect. Effects are labeled with estimated coefficients. The strength of the direct model is greatly reduced after mediation, suggesting that sex mediated neural measures in explaining strategy selection. See also Table S1. Graphs depict mean ± SEM. Asterisks marked significant effects (*: p < 0.05 **: p < 0.01 ***: p<0.001).

Article Snippet: Colorbar = Pearson’s r. D ) cFos gene expression in NAc and PFC is significantly correlated with the weight of PC2.

Techniques: Gene Expression, Quantitative RT-PCR, Expressing, Labeling, Selection

Journal: Emerging Infectious Diseases

Article Title: Decrease in Tuberculosis Cases during COVID-19 Pandemic as Reflected by Outpatient Pharmacy Data, United States, 2020

doi: 10.3201/eid2804.212014

Figure Lengend Snippet: Correlation between National Tuberculosis Surveillance System case counts and IQVIA ( https://www.iqvia.com ) projected patient counts for isoniazid (A) or pyrazinamide (B) prescriptions, United States, 2006–2019. Horizontal axes show patient counts aggregated by treatment start date, removing patients who had reported resistance to isoniazid or pyrazinamide. Vertical axes show IQVIA projected patient counts aggregated by date drug was dispensed (data are on different scales). Each point represents a month, and all data during 2006–2019 are shown. Solid black lines represent regression fit for a linear model between the 2 databases; dashed gray lines indicate 95% prediction intervals. The Pearson correlation coefficient ( r ) is shown in the lower righthand corner of each plot.

Article Snippet: We used a Pearson correlation coefficient ( r ) for the aggregated dates available in both datasets to identify the combination (IQVIA database, NTSS aggregation, and month/quarter timeframe) with the strongest correlation (highest r ), which was used in subsequent analyses.

Techniques:

Journal: Emerging Infectious Diseases

Article Title: Decrease in Tuberculosis Cases during COVID-19 Pandemic as Reflected by Outpatient Pharmacy Data, United States, 2020

doi: 10.3201/eid2804.212014

Figure Lengend Snippet: Comparison of National Tuberculosis Surveillance System (NTSS) case counts and IQVIA projected patient counts for isoniazid or pyrazinamide prescriptions, United States, 2020. A, B) Projected patient counts for isoniazid (A) and pyrazinamide (B). Horizontal axis of each plot shows NTSS patient counts aggregated by treatment start date (month), removing patients who had reported resistance. Each point represents a month in 2020. The Pearson correlation coefficient ( r ) is shown in lower righthand corner of each plot. C, D) A linear model fit to the 2006–2019 data with quarter as a covariate to predict 2020 IQVIA projected patient counts for isoniazid (C) or pyrazinamide (D). Black line indicates actual data; gray line indicates expected IQVIA counts with 95% prediction intervals. Note vertical axes are different because of different scales for isoniazid and pyrazinamide in the IQVIA dataset. NTSS, National Tuberculosis Surveillance System.

Article Snippet: We used a Pearson correlation coefficient ( r ) for the aggregated dates available in both datasets to identify the combination (IQVIA database, NTSS aggregation, and month/quarter timeframe) with the strongest correlation (highest r ), which was used in subsequent analyses.

Techniques: Comparison